Reproducibility of telomere length assessment
نویسندگان
چکیده
منابع مشابه
Reproducibility of telomere length assessment: an international collaborative study
BACKGROUND Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and uncertainty regarding the present limits of measurement reproducibility within and between laboratories. METHODS We instigated an international collaborative study of telomere length assessment: 10 different laboratories, employin...
متن کاملReproducibility of radiographs with the orthopantomograph 5: tooth-length assessment.
The precision of tooth-length assessments based on repeated panoramic radiographs made with a Siemens OP 5 was investigated in three groups of twenty patients. Two exposures of the same patient were made under three different radiographic conditions. Of the tooth lengths, nonmeasurability was found in 14% to 17%. The variability (standard deviation) of the measurements assessed from repeated ra...
متن کاملEffect of pre-analytic variables on the reproducibility of qPCR relative telomere length measurement
Telomeres, long nucleotide repeats and a protein complex at chromosome ends, shorten with each cell division and are susceptible to oxidative damage. Quantitative PCR (qPCR) is a widely-used technique to measure relative telomere length (RTL) in DNA samples but is challenging to optimize and significant lab-to-lab variability has been reported. In this study, we evaluated factors that may contr...
متن کاملLeukocyte telomere length: the telomere tale continues.
In culture, replicating human somatic cells display progressive telomere shortening. Ultimately, such cells either undergo apoptosis or enter a state of replicative senescence that is triggered by critically shortened telomeres. Accordingly, telomere length is an index of both the replicative history and the replicative potential of human somatic cells in culture (1). Most replicating human som...
متن کاملTelomere Length and Aging
Telomeres, the TTAGGG tandem repeats at the ends of chromosomes, become progressively shortened with each replication of cultured human somatic cells (reviewed in Wong and Collins (Wong & Collins 2003)) until a critical length is achieved, at which point the cell enters replicative senescence. This situation can be reversed by the enzyme named telomerase that is responsible for Telomere Length ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Epidemiology
سال: 2015
ISSN: 0300-5771,1464-3685
DOI: 10.1093/ije/dyv167